Ans. The meaning of this sentence, which is recited towards the conclusion of Ardaas (Sikh supplication), is that Guru Nanak says, whoever keeps the name of God as his/her guiding beacon in life shall always be in ascending spirits being lies in staying within God’s will every ones well
Also, in Guru Granth Sahib it is said that anyone who follows the path dictated by his/her own ego shall go astray (from the path of truth) and suffer.
ਆਪਣੈ ਭਾਣੈ ਜੋ ਚਲੈ ਭਾਈ ਵਿਛੁੜਿ ਚੋਟਾ ਖਾਵੈ॥
(SGGS, P. 601)
Those who practice Naam always remain within the will of God; such persons always consider the well being of everyone as their foremost priority. In other words their wish is everyone to understand that their well being lies in staying within the will of God.
A Khalsa is votary of positivism. He believes in (spiritual) progress, day in and day out. This progress is like a whirlwind before which the dirt of sins, bigotry and barbarism cannot stand and fly away. It gives him ability to stand up to dark and wicked forces and conquer them.
Thus the essence of this edict is to always remain in a state of positive thinking and keep ones spirits high and ever ascending.